Wellbutrin Half Life Facts
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Questions and Answers
Wellbutrin SL, 100mg once a day? I was prescribed Wellbutrin SL by my doctor yesterday. I realized after I got home that it says to take 100mg once a day. After reading the paperwork that came with the meds, I learned that this is usually taken twice a day (half-life maybe?). Wellbutrin XL is the kind that is normally taken once a day. Is anyone else taking Wellbutrin (Bupropian) SR only once a day? Why would my doctor be doing this?

Cydney replied: "You typically don't start at the maximum or "normal" dose. It's lower to monitor any side effects and to see how you handle the medication...and to see if it provides any relief from your symptoms. If you are having a positive experience from the medication, your dose will be increased."

J G replied: "I take 150 mg SR once a day and that is plenty for me. You dont start at full dose. "Typical" Dose is 300mg....150 am 150 pm. But better off starting lower and seeing if that is enough. So most likely will see if you need more the next time you see Dr.....and then either up the one dose, or add a second dose....maybe go to 100 mg am 100 mg pm. If you would go on to wellbutrin too fast it could also cause seizures"

I have two questions: How long until Zoloft starts to work, and how can I deal with sexual side effects? Hi. I have been taking Prozac, and it is really helping with my OCD thinking (causing relationship problems, and paranoia about my boyfriend being a commitment phobe--he thinks that I am crazy for diagnosing him with that), but I HATE the sexual side effects. So I heard that you can take a drug holiday on Zoloft, as it has a short half-life. I quit taking Prozac, and two weeks later, the symptoms have returned. My Dr. changed me to Zoloft, and I started taking it today. 1. How long til Zoloft begins to work (not full effect, just onset of action)? 2. How do you deal with sexual side effects (I also take Wellbutrin, but that doesn't help with the sex problem.)? 3. Has anyone stopped taking Zoloft for the weekend, and been able to orgasm? 4. Would you rather have your disorder and be able to have successful sex, or forfeit the ability to climax in order to not have the psychological symptoms that the drug takes away?

jaden replied: "no"

ninetynine4one replied: "Go to They will answer all these questions and more. Good luck sweetie!"

carl replied: "I don't know. but you need help girl,"

snowy replied: "I have a friend who was on Zoloft - She took it while she was pregnant and the baby had "floppy baby syndrome" for the first few weeks - he's okay now. She became addicted to it and had really bad withdrawal symptoms - so bad she could't be alone with her kids. It took about 6 months for the symptoms to go away. BE CAREFUL!"

ineedahotti replied: "Tough question- It takes 4-6 weeks to really have an effect, although the sexual side effects show up much sooner. Most all of the SSRI type meds that you mentioned have the same side effects.Whether the side effects are worth the positive effects is a call you have to make . My wife has been on ssri meds for 5 years and has tried many different ones , but it seems that prozac(the original) is still the most effective overall, and has the least side effects. I have heard that SSRI is an acronym for Shitty Sex Really Ironic Good luck."

Mephistopheles replied: "Stopping Zoloft without Medical supervision is very, very risky. Please don't do it. It has been known for people to commit suicide when stopping this drug abruptly. At best it will bring back your sympthoms with renewed intensity and put your recovery back. Zololf will take a few weeks to work but it takes a few months to come off depending on your dosage."

Thin Kaboudit replied: "Zoloft is, I believe, an SSRI-type drug, so you can't "turn it on and off" like a light switch. Any side-effects you might get as a result of using it will not appear "overnight" and neither will they disappear if you miss your dose for a couple of days! You may be able to take a "drug holiday" as you call it for a week or so every once in a while, but I think you probably need to discuss this whole course of treatment with your doctor some more. A drug you are reluctant to take might do you more harm than good!"

bkythatsme replied: "Zoloft will have a full effect within 2-4 weeks. Since sexual side effects are common with Zoloft, you may want to discuss alternatives with your psychiatrist. I do not recommend stopping your meds for the weekend without discussing it with your psychiatrist first."

MRose replied: "ive been on zoloft for over a year now, 150mg. i was on several different things before it, and its been the best for me. but its different for every person. it only takes about 2 weeks for you to start feeling it.mine didnt even seem to take that long, honestly. but it could be different if youre going off of prozac and straight to zoloft, i dont know. i dont really feel any sexual side effects. here in the past 2 months, ive been less interested in it, but i dont have a boyfriend, and im on other medications as well, so i cant blame it on the zoloft. but i never felt like i had a problem with it when i was having sex i stopped taking all my meds for about 3 days, and went through terrible withdrawl. like i said, itmight not be just the zoloft, but i wouldnt recommend stopping them cold turkey, even for a few days. i've never noticed an effect on my orgasm. none of the meds im on seems to have changed it. my climax is fine, but if i had to give it up to be happy and healthy, i probably would. orgasams only last a few seconds, and you cant live your life from orgasm to orgasm (even though it would be great if you could...) you have to be able to function in between them as for stopping medication for good sex, i dont think thats an option for me. some people deal with depression worse then others. i'm miserable without medication, and i was very promiscous and didnt give a damn about myself. i'd rather be healthy and happy on medication then to worry about successful sex. but my depression could have a different intensity then yours. if you think that you can do ok without the meds, and you feel like your sex life is more important and would benefit from not being on any medication, then go for it. (but talk to your doctor first, like i said, stopping cold turkey is NOT a good idea)"

Dean C replied: "I am not a Doc or anyone who gives ACTUAL medical advice, but here are my comments: Talk to you doctor aout these things, there IS a solution out there for you. I do NOT think that Zoloft (or any of its related meds) are off and on medicines. Talk to your doc about viagra-either for you or your partner. Being alive, able to heal, and enjoy all of life later beats going off meds and being miserable now."

excluding wellbutrin (it does not help at all) what is the best ant-depressant for a man with least sexual sid sexual side effects. my husband is 64 and i just turned 40, up until about a year ago we had a great sex life. he has been on some kind of anti depressant since 1985. he really needs them, but lately we have noticed an inability to climax or if he does it takes sooooooooooo long to get there. He stopped the prozac 40 mgs and within two weeks our sex life was great again, but soon thereafter he became depressed and irritable, then i finally cslled his doc and got him back on prozax starting with 20mgs and our sex life was still good, but eventually the same problem occcured. then his doc put him on lexipro and added klonapin, well not only did he have a difficult time reaching orgsasm then he began to experience erectile dysfunction. having enough of no sex, he stopped the lexapro and for about two weeks we had the best sex ever, but the long half life ended and he became the most irriitable, irrational man, he was biting everyones head off. he does have a very stressful job, we both d we began fighting over little things, arguing all the itme, he was always tired, NEVER EVEN IN TH EMOOD FOR SEX, SO THE POINT WAS DEFEATED he lost all desire, never initiated sex and when i did he had no interest, ion the rare occasion we did he could achive orgasm quickly but there was no intimacy, no emotionsa connection. i could not live like that anymore so back to the doc, noe he is back on the lexipro, still on all his other jmeds for high blood pressure, heart medication, ambien to sleep hydrocodone for pain, xanax for anxiety and now chantix -he did quit smoking. he has slowly returned to his fun pklayful self, also added provigil for narcelepsy, but we have not tried to be intimate yet, it has been two weeks. i am just so happy to have him bag, we cuddlle, we kiss we touch we talk etc. i am just wondering if there is an anti depressant out there that does not cause such serious side effects, taking into account all the other meds he has to take. any help greatly appreciated,

peahiwahine replied: "Almost every medication out there for depression make it more difficult for men to climax during sex. You may end up having to get him two medications - 1 to treat the depression and 1 to treat the side-effects. I don't know if something like Viagra in addition to an anti-depressant would be helpful or appropriate. The best place to go is to a psychopharmacologist. They are psychiatrists with specialized training in medication. It's like having a doctor and pharmacist in one. I'm also extremely concerned about all the other psych medication he is on, like Ambien and Xanax. All the more reason you should take him to a specialist. I do want you to know that there *are* options but while I'm experienced I'm not a replacement for a physician. DO ask about a medication called Hydroxyzine Pamoate. It has very few side-effects and can be used to treat anxiety and sleep."

akeru1 replied: "Good heavens -- your husband is taking a LOT of different medications. There are bound to be some interactions between them, as well as their individual side effects. The underlying medical issues (such as narcolepsy, anxiety, etc) can also cause sexual problems. I agree with the previous respondent -- you should persuade your husband to consult a psychopharmacologist who can sort out the medication tangle and see what can be done for the sexual issues without affecting any essential medications. (And I would also consult his doctors about whether ALL those medications are really necessary, and interact well together.) Wellbutrin is generally considered the least likely antidepressant to affect sexual response. Among the SSRI antidepressants, Celexa/Lexapro generally has fewer sexual side effects than Prozac, Zoloft, etc. If neither of these antidepressants worked for your husband, then specialist help really is needed. Good luck to both of you. It must be a very difficult situation."

Wellbutrin withdrawal side effects? I've been on WB for just over 2 months and had some side effects I can no longer live with. Among them is insomnia. I was taking 150 XL. the sleeping improved a LITTLE bit, in that I could sleep at times with the aid of only one Benadryl. But my sleep has just not been the same, and I can't rely on sleep meds. I recently lowered my prescription to 75mg, and in the normal release form (they don't make XL less than 150). I take one just in the AM. I'm hoping that maybe this lesser dosage and the shorter half life will reduce the night time side effects. Two days now, and I'm having withdrawal side effects, including flu like symptoms, depression, and TOTAL fog. I just don't feel altogether there. Also, last two nights have been absolutely miserable. Two benadryls last night did nothing but make me loopy and freaked out, since I was drugged, but not sleeping. Up all night. I'm hoping this will improve VERY soon. Anyone experience this? How long does it take for the withdrawal effects to go away? I'm assuming they're withrawal symptoms, since I've reduced my dose in half. I would really appreciate some feedback! I did consult my Dr., by the way, though it was kind of a formality. He's not a specialist, and basically just said he doesn't see a problem with my getting off of it. Also, I was never too depressed as much as very very moody. Also took it for ADD. It does help me stabilize my moods, but I can't live with the insomnia. It's also lowered my sex drive.

mrkittypong replied: "I was able to stop it cold turkey at least 3 times without any side effects, it's weird how people react differently to meds. I am otherwise very sensitive to meds."

Iqbal E replied: "Do not reduce your med without consulting a physician. The withdrawal symptom will last for four to five days."

How common is it for ER doctors to "mis"diagnose patients? For a few weeks, I've been having uncontrollable head & body shaking & jerking @ night, when I try to go to sleep. Last night & this morning, it was the WORST, & I was wondering if I was having acute seizures. The second that my body relaxes , & I drift off to sleep, my body jerks, but my head jerks the hardest. The 1st few weeks, I thought it was a new tic from my Tourette's. But I guess not. I went to the ER this morning, & the doctor asked me about my psych medications. I HATE when they turn my physical problems into psychological problems & want to believe I'm a hypochondriac! I'm NOT. He even came in the room & caught me off guard, jerking as I was drifting off to sleep, & he said, "Is this the kind of jerking you experience when you sleep?" I said "yes". & he asked me what meds I take. I told him I take Luvox, Clonidine, & Wellbutrin. & he said that he was going to prescribe an antihistamine because (in his opinion) the psychiatrist put me on the wrong meds. He prescribed me 50 mg of HYDROXYZINE. He put the diagnosis as "Muscle spasms", & he gave me a paper on muscle CRAMPS. He insisted that my psychiatrist put me on the wrong meds, in which she didn't. I was like, "No, because I've been on these meds for months & months, & this head jerking didn't start until a few weeks ago." He was like, "Yeah, whatever!" I was only there for an hour & a half. I was like, "Wow! This was the QUICKEST ER visit I've ever had in my LIFE!" My friend & 1 of her coworkers were with me, & my friend was VERY pissed because she KNEW he didn't handle my situation correctly! She said he was 1 of those lazy ER doctors who only care about making $$ & not helping patients. But anyway, she said that if I was complaining of uncontrollable jerking, the Dr. shouldn't have ordered simply a blood test to check my salts & potassium levels. He said they were fine, after the test. So since nothing from the blood test showed up wrong, he felt it was all in my head, & I was being a hypochondriac, based on my psychiatric diagnoses, such as OCD, Tourette's (neurological), anxiety, & depression. My friend said he was supposed to do a CT scan, an MRI, or something. & he just gave me a "diagnosis" based on the complaint I had. I was thinking, "Wow! I never knew we have muscles in our head." That visit really was a waste. I started not to go, but my friend URGED me to go because you never know what could happen. So when I got back home, she told me to google "uncontrollable head jerking during sleep". & I found out about this condition, called myoclonus. & that described EXACTLY what I was going through! The second that my body relaxes, I fell that head & body jerk that feels like an electrical brain impulse or something. That's what made my friend think I might've been having acute seizures. & when I told the Dr. & 1 of the nurses @ the hospital, they said, "No. They weren't seizures because you would've bit your tongue, & it would've bled." My friend's sister has seizures, & she said that her sister doesn't bite her tongue with EVERY seizure. My arm & leg joints would feel weak, as soon as I drift off to sleep, & then I feel that electrical jerk in my head. & my arms & legs flail & flap all over the place. I also read that with myoclonus, your body is tricked into believing it's dying, so you have that electrical brain impulse to alert you that your body is not dying. & I also read that I can be having myoclonic seizures &/or acute seizures. & that's what my friend told me BEFORE I even went to the ER. So my friend was right. ***Sorry so long, but I had to tell EVERY detail in order for you to understand what happened.

amandafrknmarie replied: "They are idiots in my opinion. I went to the same ER doctor 12 times before he told me I had a seizure. You don't always have to bite your tongue. They are idiots, and they are always in a rush and they can misdiagnose you over and over. So next time you go there, take control and demand the name of a neurologist or else you wont get anywhere."

brookielyn replied: "It's definitely possible that he just wanted to move you along like cattle and decided on an "easy" diagnosis. A lot of doctors will do it also because many don't want to deal with it and brush it off as psych problems. I don't think the majority of doctors are like this, but you know what they say about one bad apple spoiling the bunch. You should make an appt. with your primary care physician and talk to them about it since they'll know more about your history and your conditions than someone who reads a tiny synapsis of it would. Good luck, and yeah it could easily be seizures."

KTD replied: "I went to the doctor once because I was having chest pain and they did all these tests. And they said that my heart may be racing because I take Adderall XR. So I am prescribed 20mg Adderall XR regularly and they sent me home with Ambian to help me sleep and Amphetamine salts 15mg, which is basically the generic for Adderall, not Adderall XR. So they gave me 15mg, which is not extended release and so that was putting more drugs in my system at once, versus the 20mg of XR which puts 10 in your system at one point and 10 later. So basically they increased the amount of adderall I was taking which screwed me up more and I went to my psychiatrist and he was freaking out saying how those doctors SHOULD NOT be prescribing drugs like this an they don't know anything about these things. Then a year later I was hospitalized again, ran all the same tests and more and found nothing. And finally my roommate said that she has mitral valve prolapse and that maybe I should see a cardiologist. So my mom talked to my aunt and it turns out my aunt has it also, (oddly enough my roommates moms sister, her aunt has it also) and after going to a cardiologist they find out that I have mitral valve prolapse and that I shouldnt be taking any sort of a stimulant and so they put me on a beta blocker. Long story short, the doctors at hospitals do not know you long enough and know enough about your history to know if you are a hypochondriac or schizophrenic for pete's sake. They can mis-diagnose things and perhaps not catch things and let you go home and then have something worse happen. Nobody is perfect, and I like to believe that they are all just trying their best, and thats all you can hope for. Hope all is well, take care."

i take the blame replied: "Everyone has myoclonic jerks, it's that sensation you get when you're falling asleep, and you feel like you're falling and "jump". It's normal. ER doctors are overworked and dealing with probably 20 cases at one time, on top of any emergencies that come in, I know that it's frustrating. As an aside, if you had a seizure, you wouldn't be aware of it happening. You wouldn't feel it happening."

Tex replied: "Do not forget that a ER doctor is an Emergency Room physician. Which means patch and stabilize. They are the best doctors at quick fixes (some of the hardest and intense medicine). However, they do not have the extra time to do in depth research (and not really the training for it as well) that is probably needed for your case. Get an appointment with your regular doctor for a second opinion / follow-up. This is standard practice for almost all cases coming out of the ER."

Can you have a relapse on 150mg Wellbutrin after 1 year of taking it? I have been experiencing alot of depression for the past 1.5 weeks. I was working 70-80 hours and only getting 3-4 hours of sleep, but have changed locations of my job and work my 50 hours a week and get a good nights sleep. Do you think this could have something to do with it? I have no desirer to do anything and should be very happy with the better quality of life I now have. My stress level has been cut in half and I feel like I am on no medication at all.

bugzilla replied: "Maybe you are adjusting to the change of life style? Do you like your new job even though the hours are better? The treatment dose for Wellbutrin, according to my doc, is 300 MG so you might want to ask your doctor about that. I was on 150mg for about a month, and then was increased to 300 mg. Good luck."

Sue B replied: "If you get no sleep you can feel more depressed. Try to get more sleep and exercise for 30 minutes a day. Walking is good because it will clear your head and the feel good hormones in your brain will be released. This will help lift your spirits. I'd try this for two weeks and if it didn't help I'd call the Dr to make an appointment to go in and talk to him. Together you can decide if you need to up your dosage. Good luck."

rgriffis68 replied: "Hmmm. Well that work/sleep/stress situation could definitely be the cause of it. And it may only be temporary. How well were you doing on the 150mg of Wellbutrin before all this? I achieved a 2-year full remission of depression on 600mg of Wellbutrin many years ago. Then it caused a urinary problem (common side-effect). Then it just plain wore off, only very slowly over a 18-month period. You may just need more of it, or you may need to try something else. You need to work it out with your prescribing psychiatrist. You need to get on that right away. You won't get a full answer on this forum. Trial and error, working with your shrink is how it's done. Good luck."

Sandi Beach replied: "You can build up a tolerance to any medication after being on it for awhile. Every person is different & so are their reactions to meds. Contact your Dr to discuss a possible increase of dosage or perhaps a change to a different medication altogether. There are so many choices available."

Please help me!!!!!!!!!!!!!!!!! It's long sorry!!!!!!!!!!!!!? Okay, I'm a 21 y/o female and have been taking meds for depression and anxiety. I'm going to talk to the nurse pract at my university today on the phone. I'm def going to request she taper me off my current meds paxil and wellbutrin they're not working. I'm sicker than before. I've missed a lot of class and somedays I can't get out of bed. Also, lately, I've been suffering for constipation and vomiting. Ummm. not sure what that is from. The wellbutrin was causing me to shake in my sleep...my mom told me. The nurse prac. told me to stop it completely. I asked her would that make me sick; she said I should be fine. Well, I tried and I wasn't fine. I wound up sicker than on the meds, and had to just keep taking them. I went to accute care and they referred me to a psychiatrist that isn't accepting new patients. I went some places and called around and wound up at square one back with the nurse pract that's rude to me. Last time I told her the meds were making me sick; she said well what do you want to do, do you want to keep taking them. I just got a phone call from the nurse. She says the nurse prac isn't even there but should be in later today. She asked me what was going on. I told her and told her I wanted to be taken off both meds b/c they're not correcting the symptoms but just added side effects. She told me she'd tell the nurse pract. I'm sort of exhausted. I'm tired of having to talk to someone to talk to someone to talk to someone to talk to who I need to. This is the second time I've had to explain what's going on just today and the person that can help me isn't even there. I know this is long but I'm a really patient person, but I've been on meds for almost half my life and I'm at one of the lowest points in my life and the people that re PAID to help me act like I'm a bother. So what should I do? Should I go off the meds completely? Or is there a new drug out there that's effective for someone with very severe depression and anxiety? I say new b/c I've been on just about everything now. I don't know why this stuff doesn't work or it just works for a few months and stops. Thanks so much for reading this and any info you can give me, I'm obviously lost.

Stanzin D replied: "fuck man!!! who will answer its very long question."

grandwoman replied: "I would not go off the meds immediately and cold turkey, but I would definitely taper. Let the people know what you plan to do; likely if you are adamant in telling them you are going to stop meds, they'll pay attention. Do a google on quitting paxil/wellbutrin. You'll find some very useful info. Good luck!"

marj71 replied: "In all honesty I think you should take a look at your diet . A lot of times if you aren't getting enough minerals/vitamins from the foods you eat or if you don't have a regular exercise routine, depression and anxiety are often the side effects. Try to balance these things out, go off the meds and see where you stand. Good nutrition is key to health and happiness. Good luck."

Cyd replied: "I've been exactly where you are and I know how frustrating it is. The meds you are on do need to be tapered off or you get withdrawal symptoms that suck. When you mentioned severe depression and anxiety along with sometimes the meds work and then just stop a warning bell went off. When that happened to me that's when my psychiatrist realized I was Bi-polar we started a whole different kind of medications some worked some didn't I am now on the right combination and have been stable for about a year. I would urge you to keep trying to find a psychiatrist they could make a better diagnosis for you. You may want to mention this to your nurse practitioner and see if she can come up with a different type of meds for you to take. I know what a pain retelling your story is but keep telling it to anyone in the medical field you can until you get some real help. If you need someone to talk to or even blow off steam to feel free to e-mail me. Cyd"

Edward M replied: "I agree with a lot of what "Cyd" wrote. Good guy. I spent far too many years in the "poor-quality therapist / wrong meds hellish-go-round". In the early years, I didn't have enough of a reference point to know that I deserved better care and professional accountability, or what the standards of care looked like. What I eventually learned through painful trial and error was that this stuff is SERIOUS, and the consequences of not getting qualified help can range all the way into life threatening. I know this first-hand. We know the power of meds. The right one(s) for an individual can produce miracles(my exp.) and the wrong one(s) can kill you(almost my exp.). You can't afford to make changes on your own, but you also can't afford to have irresponsible professionals apathetically-prescribe or "blind-exploration" prescribe. It's only my opinion, but I would suggest finding a qualified private therapist to discuss what has been going on over at least several sessions, for continuity, and asking for a referral psychiatrist known to the therapist for a med evaluation. Then track it w/ the therapist once a month or so. And after that, report your prior failure of care experiences to the proper admin. These people have ethical and legal responsibilities. You might save some one else's sanity or life. I wish you the very best of luck and I'll be thinking about you. Email "Cyd" and I'll see about getting my email open as well. Take care, Edward Oh, I almost forgot. Nausea is one of the known common side-effects of Welbutrin(& shakiness/lost sleep because it is a dopamine & norepinephrine re-uptake inhibitor, and mild SSRI). Paxil put me in the hospital. Remember, that was MY experience, and everyone responds differently, but Paxil does have some pretty bad reviews. I have been on Celexa or Lexapro for ~7yrs now w/ excellent results. Just FYI, not a recommendation. Let the psychiatrist do his job. Good luck and keep walking forward."

h replied: "I am suggesting you homeopathic medicines. This may sound silly, but these have great powers. For long, I have many problems, and I have been benefited quite a lot from these simple medicines. First is Nux Vom. 30c, take five pills at bed time Second is Bacopa Monniera Mother Tincture 5-10 drops or Bacopa Monniera 1x 5 pills at bed time. If you do not find it, take Damiana Mother Tincture 5-10 drops at bed time. Take these along with your psy. medicines. After 1 week or so, you will start feeling better and can try to slowly reduce your psy. medicines. If you benefit from the medicines I have told, you can also take them once more in the morning. Apart from the above, I have other advices from you. For long, I have observed that morning(specially dawn) is natural healer of mind. Even if in the beginning, you do not find yourself being able to wake up early, try to wake up s early as possible. And then take a walk, or do some exercise. If you feel tired, take a very small nap in the daytime. Also try to to go to bed before 10 pm. I hope this would definitely help you. Even if it does not, please mail me at. I think I will be able to give you good suggestions from my experience. As a patient of depression, I know that getting interest in doing a work is very difficult for a person with depression. So we need to use the healing techniques which are most effective and avaiable free of cost from nature and change ourselves to know the joy of life so that we learn not to get depressed further or to get less depressed. Have a nice time..Bye."

meggus31 replied: "What you need to do is get the hell away from a nurse prac who is prescribing your anti depressants. Bad move. She obviously doesn't know what she is doing especially telling you to quit your meds cold turkey. You should know it's not smart to quit them cold turkey. Find yourself an psychiatrist to prescribe for you. A new med, Pristiq is supposed to be pretty good."

Happy Medicine, suggestions for choosing antidepressant that works? I understand that only my medical doctor can decide the right antidepressant for me, but everytime I visit my primary care provider, they just want to rush me out of the office. Im not tested, yet I relate my depression and awful feeling to her and from that she suggests therapy and medicine. Im 20 year old female whose suffering from life-altering depression. I left school on a medical leave because of it, and usually sport and active obsessed, all I do is lay and sleep. Sometimes, I cant even get out of bed to work. I was on 10mg of Paxil for two months, which seemed to do nothing at all. I was then put on 150mg of Wellbutrin XL and have been a month and a half with NO difference. I know everyone is different, and even when I see my doctor, to no prevail am I helped. Is Prozac, Zoloft, Cympalta, Effexor..any worth bringing up? I just want to be normal and happy again.

VetSupporter replied: "I am on a combination of 300mg. Wellbutrin XL and 40mg. Prozac. No it didn't put me in lala land, it made it so I feel like living again instead of suicide. (I had a plan). I have a wonderful loving husband so when I wanted to end it all I knew something wasn't right and got some help. Sometimes it is just a chemical imbalance that you have no control over. Sometimes one medicine doesn't work by itself. You need a combination. One did a little by itself but with both together I can live again."

nana4141 replied: "http://www.montana.edu/health/nutrition/dorm.html"

pirate00girl replied: "you might be a lot better off going to a psychiatrist...they know the meds like the backs of their hands. primary care docs basically listen to what the drug reps are pushing at the time. (not all of them of course). i've been on most of the meds you've listed. been taking cymbalta for 9 months and it's like a miracle drug for me. effexor is good too. i've literally had to yell at my primary care doc just to get her to look at me, and listen to what i have to say. i know it's really frustrating. keep on fighting for what you need. very best of luck to you. EDITS: "vet" is absolutely correct...a combination is often used, but i doubt you will get it from a primary care general practice doctor. my mom and my son take a combination of several meds."

sweet sue replied: "You really need to see psychiatrist. Only a trained psychiatrist can evaluate you and decide on an appropiate course of treatment. It is not unusual to go thru several medications to find the one that works for you. Your life is in serious trouble, the longer you let this go the worse it's going to be. Psychiatrists have alot of experience with meds and they can find the right one (or combo) that works for you. Many people take more than one drug. I take 4 and it works for me. I have been thru all those you listed and more. Seeing a psychiatrist does not make you crazy. There is nothing to be ashamed of. Your health insurance will pay for it. The only thing crazy about it is not getting the help you need and wasteing your time in bed and missing school. Good luck!"

Melissa A replied: "Everyone's body chemistry is different, so you have to talk to a psychiatrist to see what he thinks will work best for you. I am on Lexapro, mainly for anxiety, but it is good for depression as well. I really like it, so that is something you could ask to try."

♥ Hallie Love ♥ replied: "I have Bipolar II. I guess anti-depressants never really worked for me either. Lexapro worked initially, but that's because it flipped me into a hypomanic stage. I became really productive and happy. If none of them are working, ask you doctor about Bipolar II. I went through periods of being normal and happy and being depressed and lethargic like you. -Hallie Love-"

CLICKHEREx replied: "See depression treatments/resources at on page 2. Antidepressants don't work for some people: doctors haven't got time to tell you about other methods, and their patients expect the answer to come in the form of a pill. Try the multidimensional approach, instead, including Cognitive Therapy, relaxation techniques, exercise, diet & supplements, occupational therapy, herbal remedies, and the others."

Have you ever had an ER case for a physical problem where the Dr. wrongfully thought you were a hypochondriac? For a few weeks, I've been having uncontrollable head & body shaking & jerking @ night, when I try to go to sleep. Last night & this morning, it was the WORST, & I was wondering if I was having acute seizures. The second that my body relaxes , & I drift off to sleep, my body jerks, but my head jerks the hardest. The 1st few weeks, I thought it was a new tic from my Tourette's. But I guess not. I went to the ER this morning, & the doctor asked me about my psych medications. I HATE when they turn my physical problems into psychological problems & want to believe I'm a hypochondriac! I'm NOT. He even came in the room & caught me off guard, jerking as I was drifting off to sleep, & he said, "Is this the kind of jerking you experience when you sleep?" I said "yes". & he asked me what meds I take. I told him I take Luvox, Clonidine, & Wellbutrin. & he said that he was going to prescribe an antihistamine because (in his opinion) the psychiatrist put me on the wrong meds. He prescribed me 50 mg of HYDROXYZINE. He put the diagnosis as "Muscle spasms", & he gave me a paper on muscle CRAMPS. He insisted that my psychiatrist put me on the wrong meds, in which she didn't. I was like, "No, because I've been on these meds for months & months, & this head jerking didn't start until a few weeks ago." He was like, "Yeah, whatever!" I was only there for an hour & a half. I was like, "Wow! This was the QUICKEST ER visit I've ever had in my LIFE!" My friend & 1 of her coworkers were with me, & my friend was VERY pissed because she KNEW he didn't handle my situation correctly! She said he was 1 of those lazy ER doctors who only care about making $$ & not helping patients. But anyway, she said that if I was complaining of uncontrollable jerking, the Dr. shouldn't have ordered simply a blood test to check my salts & potassium levels. He said they were fine, after the test. So since nothing from the blood test showed up wrong, he felt it was all in my head, & I was being a hypochondriac, based on my psychiatric diagnoses, such as OCD, Tourette's (neurological), anxiety, & depression. My friend said he was supposed to do a CT scan, an MRI, or something. & he just gave me a "diagnosis" based on the complaint I had. I was thinking, "Wow! I never knew we have muscles in our head." That visit really was a waste. I started not to go, but my friend URGED me to go because you never know what could happen. So when I got back home, she told me to google "uncontrollable head jerking during sleep". & I found out about this condition, called myoclonus. & that described EXACTLY what I was going through! The second that my body relaxes, I fell that head & body jerk that feels like an electrical brain impulse or something. That's what made my friend think I might've been having acute seizures. & when I told the Dr. & 1 of the nurses @ the hospital, they said, "No. They weren't seizures because you would've bit your tongue, & it would've bled." My friend's sister has seizures, & she said that her sister doesn't bite her tongue with EVERY seizure. My arm & leg joints would feel weak, as soon as I drift off to sleep, & then I feel that electrical jerk in my head. & my arms & legs flail & flap all over the place. I also read that with myoclonus, your body is tricked into believing it's dying, so you have that electrical brain impulse to alert you that your body is not dying. & I also read that I can be having myoclonic seizures &/or acute seizures. & that's what my friend told me BEFORE I even went to the ER. So my friend was right.

MDMA NO WAY replied: "I would go to a different ER or make an appointment with your regular Doc. That really sucks!"

Do all antidepressants take over a month to start working? I first tried antidepressants (after much coaxing) about a year and a half ago. I took both Prozac and Wellbutrin for about 9 months. To my surprise they actually did have a huge positive effect on just about every aspect of my life. However, both took well over as month (probably closer to 2 months) before I noticed/felt any marked changes. I stopped taking them both b/c my life had seemingly improved so much. Now it's all gone back to hell. I became pretty desperate (my job, school, and relationships were getting pretty strained) and tried getting back on medication, but after a month and a half of waiting for it to work, I stopped seeing my doctor and decided alcohol would probably work just as well. I really want to try getting back on them again, but preferably one that doesn't have a 2 month waiting period. Sorry that was long... I'm tired and ranty...

Caroline Springs replied: "myne took 2 weeks to start working...im off them now."

Pete replied: "Most anti-depressant, particularly the SSRIs like prozac and zoloft, can start to have effects within a few days but they do typically take 6-8 weeks before they're having their full effect. Wellbutrin is often added as an "enhancer" to boost their effects."

CurlyQ replied: "Effexor worked within three days for me. Others never worked."

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